XNAS 10 Sep, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.50 per share. | 14 Dec 2024 | 1,300,000 | 2,978,833 (0%) | 0% | 0.5 | 650,000 | Ordinary Shares |
| John V. Oyler | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Dec 2024 | 1,300,000 | 10,100,500 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 188.79 per share. | 10 Dec 2024 | 1,300 | 5,225 (0%) | 0% | 188.8 | 245,428 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 187.60 per share. | 10 Dec 2024 | 6,350 | 6,525 (0%) | 0% | 187.6 | 1,191,280 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 186.99 per share. | 10 Dec 2024 | 9,266 | 12,875 (0%) | 0% | 187.0 | 1,732,647 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 185.73 per share. | 10 Dec 2024 | 9,956 | 22,141 (0%) | 0% | 185.7 | 1,849,167 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 184.83 per share. | 10 Dec 2024 | 7,063 | 32,097 (0%) | 0% | 184.8 | 1,305,473 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 183.60 per share. | 10 Dec 2024 | 2,600 | 39,160 (0%) | 0% | 183.6 | 477,369 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 10 Dec 2024 | 41,760 | 41,760 (0%) | 0% | 6.5 | 271,440 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2024 | 542,880 | 3,257,287 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 195.67 per share. | 10 Dec 2024 | 300 | 0 (0%) | 0% | 195.7 | 58,700 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 194.01 per share. | 10 Dec 2024 | 725 | 300 (0%) | 0% | 194.0 | 140,655 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 192.61 per share. | 10 Dec 2024 | 1,374 | 1,025 (0%) | 0% | 192.6 | 264,641 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 191.78 per share. | 10 Dec 2024 | 993 | 2,399 (0%) | 0% | 191.8 | 190,435 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 190.57 per share. | 10 Dec 2024 | 1,833 | 3,392 (0%) | 0% | 190.6 | 349,312 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 191.22 per share. | 26 Nov 2024 | 12,293 | 7,388 (0%) | 0% | 191.2 | 2,350,704 | American Depositary Shares |
| Wang Xiaodong | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.50 per share. | 26 Nov 2024 | 38,461 | 40,468 (0%) | 0% | 6.5 | 249,997 | American Depositary Shares |
| Wang Xiaodong | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 191.24 per share. | 26 Nov 2024 | 2,725 | 883 (0%) | 0% | 191.2 | 521,117 | American Depositary Shares |
| Wang Xiaodong | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 187.16 per share. | 26 Nov 2024 | 4,425 | 36,043 (0%) | 0% | 187.2 | 828,172 | American Depositary Shares |
| Wang Xiaodong | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 191.05 per share. | 26 Nov 2024 | 700 | 19,681 (0%) | 0% | 191.0 | 133,732 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 187.61 per share. | 26 Nov 2024 | 300 | 35,743 (0%) | 0% | 187.6 | 56,282 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 189.03 per share. | 26 Nov 2024 | 600 | 5,083 (0%) | 0% | 189.0 | 113,418 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 189.17 per share. | 26 Nov 2024 | 2,700 | 26,768 (0%) | 0% | 189.2 | 510,748 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 191.89 per share. | 26 Nov 2024 | 883 | 0 (0%) | 0% | 191.9 | 169,436 | American Depositary Shares |
| Wang Xiaodong | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 188.08 per share. | 26 Nov 2024 | 1,186 | 5,683 (0%) | 0% | 188.1 | 223,060 | American Depositary Shares |
| Wang Xiaodong | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 191.96 per share. | 26 Nov 2024 | 6,981 | 0 (0%) | 0% | 192.0 | 1,340,087 | American Depositary Shares |
| Wang Xiaodong | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 190.31 per share. | 26 Nov 2024 | 1,475 | 3,608 (0%) | 0% | 190.3 | 280,703 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 191.81 per share. | 26 Nov 2024 | 407 | 6,981 (0%) | 0% | 191.8 | 78,066 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 189.76 per share. | 26 Nov 2024 | 200 | 26,568 (0%) | 0% | 189.8 | 37,952 | American Depositary Shares |
| Wang Xiaodong | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 188.55 per share. | 26 Nov 2024 | 400 | 29,468 (0%) | 0% | 188.5 | 75,419 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Nov 2024 | 499,993 | 7 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 187.14 per share. | 26 Nov 2024 | 1,014 | 6,869 (0%) | 0% | 187.1 | 189,765 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 187.98 per share. | 26 Nov 2024 | 5,875 | 29,868 (0%) | 0% | 188.0 | 1,104,391 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Sale of securities on an exchange or to another person at price $ 190.32 per share. | 26 Nov 2024 | 6,187 | 20,381 (0%) | 0% | 190.3 | 1,177,517 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 236.37 per share. | 08 Oct 2024 | 1,452 | 0 (0%) | 0% | 236.4 | 343,209 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 235.41 per share. | 08 Oct 2024 | 2,059 | 1,452 (0%) | 0% | 235.4 | 484,715 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 234.27 per share. | 08 Oct 2024 | 694 | 3,511 (0%) | 0% | 234.3 | 162,585 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 233.00 per share. | 08 Oct 2024 | 62 | 4,205 (0%) | 0% | 233 | 14,446 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 231.05 per share. | 08 Oct 2024 | 371 | 4,267 (0%) | 0% | 231.0 | 85,718 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 230.05 per share. | 08 Oct 2024 | 2,827 | 4,638 (0%) | 0% | 230.0 | 650,350 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 229.25 per share. | 08 Oct 2024 | 2,535 | 7,465 (0%) | 0% | 229.2 | 581,139 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 236.37 per share. | 08 Oct 2024 | 896 | 0 (0%) | 0% | 236.4 | 211,787 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 235.41 per share. | 08 Oct 2024 | 1,272 | 896 (0%) | 0% | 235.4 | 299,445 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 234.27 per share. | 08 Oct 2024 | 428 | 2,168 (0%) | 0% | 234.3 | 100,269 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 233.00 per share. | 08 Oct 2024 | 38 | 2,596 (0%) | 0% | 233 | 8,854 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 231.04 per share. | 08 Oct 2024 | 229 | 2,634 (0%) | 0% | 231.0 | 52,909 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 230.05 per share. | 08 Oct 2024 | 1,747 | 2,863 (0%) | 0% | 230.0 | 401,897 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 229.25 per share. | 08 Oct 2024 | 1,565 | 4,610 (0%) | 0% | 229.2 | 358,770 | American Depositary Shares |
| Shalini Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 17,238 | 17,238 | - | - | Share Option (Right to Buy) | |
| Shalini Sharp | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 Sep 2024 | 8,151 | 8,151 (0%) | 0% | 0 | Ordinary Shares | |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 237.10 per share. | 30 Sep 2024 | 1,202 | 0 (0%) | 0% | 237.1 | 284,994 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 220.35 per share. | 27 Sep 2024 | 5,000 | 0 (0%) | 0% | 220.4 | 1,101,774 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 200.00 per share. | 17 Sep 2024 | 500 | 4,500 (0%) | 0% | 200 | 100,000 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 200.14 per share. | 17 Sep 2024 | 4,500 | 0 (0%) | 0% | 200.1 | 900,615 | American Depositary Shares |
| Titus B. Ball | Principal Accounting Officer | Sale of securities on an exchange or to another person at price $ 189.94 per share. | 03 Sep 2024 | 137 | 0 (0%) | 0% | 189.9 | 26,022 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 191.20 per share. | 03 Sep 2024 | 700 | 274 (0%) | 0% | 191.2 | 133,843 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 190.29 per share. | 03 Sep 2024 | 2,275 | 974 (0%) | 0% | 190.3 | 432,909 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 188.97 per share. | 03 Sep 2024 | 275 | 3,249 (0%) | 0% | 189.0 | 51,968 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 188.16 per share. | 03 Sep 2024 | 2,032 | 3,524 (0%) | 0% | 188.2 | 382,337 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 192.04 per share. | 03 Sep 2024 | 274 | 0 (0%) | 0% | 192.0 | 52,620 | American Depositary Shares |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Gift of securities by or to the insider at price $ 0.00 per share. | 12 Aug 2024 | 301,457 | 5,266,973 (0%) | 0% | 0 | Ordinary Shares | |
| Aaron Rosenberg | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2024 | 220,987 | 220,987 | - | - | Share Option (Right to Buy) | |
| Aaron Rosenberg | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2024 | 118,547 | 118,547 (0%) | 0% | 0 | Ordinary Shares | |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 160.57 per share. | 30 Jul 2024 | 834 | 0 (0%) | 0% | 160.6 | 133,915 | American Depositary Shares |
| Julia Wang | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 143.90 per share. | 01 Jul 2024 | 472 | 0 (0%) | 0% | 143.9 | 67,919 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 160.12 per share. | 24 Jun 2024 | 400 | 0 (0%) | 0% | 160.1 | 64,049 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 159.49 per share. | 24 Jun 2024 | 2,389 | 400 (0%) | 0% | 159.5 | 381,020 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 161.26 per share. | 24 Jun 2024 | 23 | 0 (0%) | 0% | 161.3 | 3,709 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 160.38 per share. | 24 Jun 2024 | 400 | 23 (0%) | 0% | 160.4 | 64,151 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 159.53 per share. | 24 Jun 2024 | 1,036 | 423 (0%) | 0% | 159.5 | 165,273 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 161.00 per share. | 24 Jun 2024 | 2 | 0 (0%) | 0% | 161 | 322 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 159.80 per share. | 24 Jun 2024 | 1,062 | 2 (0%) | 0% | 159.8 | 169,708 | American Depositary Shares |
| Julia Wang | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 155.66 per share. | 24 Jun 2024 | 899 | 0 (0%) | 0% | 155.7 | 139,938 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 159.91 per share. | 17 Jun 2024 | 376 | 0 (0%) | 0% | 159.9 | 60,127 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 159.40 per share. | 17 Jun 2024 | 608 | 376 (0%) | 0% | 159.4 | 96,914 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 158.53 per share. | 17 Jun 2024 | 297 | 984 (0%) | 0% | 158.5 | 47,084 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 156.80 per share. | 17 Jun 2024 | 300 | 0 (0%) | 0% | 156.8 | 47,041 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 155.15 per share. | 17 Jun 2024 | 300 | 300 (0%) | 0% | 155.2 | 46,545 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 154.17 per share. | 17 Jun 2024 | 906 | 600 (0%) | 0% | 154.2 | 139,680 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 153.66 per share. | 17 Jun 2024 | 1,121 | 1,506 (0%) | 0% | 153.7 | 172,250 | American Depositary Shares |
| Xiaobin Wu | President, COO & GM China | Sale of securities on an exchange or to another person at price $ 159.00 per share. | 17 Jun 2024 | 627 | 2,627 (0%) | 0% | 159.0 | 99,692 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 159.00 per share. | 17 Jun 2024 | 478 | 1,626 (0%) | 0% | 159.0 | 76,001 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 158.50 per share. | 17 Jun 2024 | 237 | 2,104 (0%) | 0% | 158.5 | 37,565 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 153.75 per share. | 17 Jun 2024 | 841 | 0 (0%) | 0% | 153.8 | 129,305 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 159.90 per share. | 17 Jun 2024 | 300 | 841 (0%) | 0% | 159.9 | 47,971 | American Depositary Shares |
| Lai Wang | Global Head of R&D | Sale of securities on an exchange or to another person at price $ 159.42 per share. | 17 Jun 2024 | 485 | 1,141 (0%) | 0% | 159.4 | 77,321 | American Depositary Shares |
| Julia Wang | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 159.74 per share. | 17 Jun 2024 | 314 | 0 (0%) | 0% | 159.7 | 50,159 | American Depositary Shares |
| Julia Wang | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 159.00 per share. | 17 Jun 2024 | 253 | 314 (0%) | 0% | 159 | 40,227 | American Depositary Shares |
| Julia Wang | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 158.58 per share. | 17 Jun 2024 | 195 | 567 (0%) | 0% | 158.6 | 30,924 | American Depositary Shares |
| Julia Wang | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 158.23 per share. | 17 Jun 2024 | 154 | 762 (0%) | 0% | 158.2 | 24,368 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 158.20 per share. | 17 Jun 2024 | 102 | 337 (0%) | 0% | 158.2 | 16,136 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 159.74 per share. | 17 Jun 2024 | 129 | 0 (0%) | 0% | 159.7 | 20,606 | American Depositary Shares |
| Chan Henry Lee | SVP, General Counsel | Sale of securities on an exchange or to another person at price $ 159.68 per share. | 17 Jun 2024 | 208 | 129 (0%) | 0% | 159.7 | 33,213 | American Depositary Shares |
| Anthony C. Hooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 16,341 | 53,755 (0%) | 0% | 0 | Ordinary Shares | |
| Anthony C. Hooper | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 34,151 | 34,151 | - | - | Share Option (Right to Buy) | |
| Olivier Raymond Brandicourt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 34,151 | 34,151 | - | - | Share Option (Right to Buy) | |
| Olivier Raymond Brandicourt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 16,341 | 16,341 (0%) | 0% | 0 | Ordinary Shares | |
| John V. Oyler | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 923,975 | 923,975 | - | - | Share Option (Right to Buy) | |
| John V. Oyler | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 490,464 | 1,812,018 (0%) | 0% | 0 | Ordinary Shares | |
| Donald W. Glazer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 16,341 | 2,718,464 (0%) | 0% | 0 | Ordinary Shares | |
| Donald W. Glazer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 34,151 | 34,151 | - | - | Share Option (Right to Buy) | |
| Qingqing Yi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 16,341 | 45,955 (0%) | 0% | 0 | Ordinary Shares | |
| Qingqing Yi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 34,151 | 34,151 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 410,657 | 410,657 | - | - | Share Option (Right to Buy) | |
| Xiaodong Wang | Director, Chair, Scientific Advisory Brd | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 108,992 | 5,568,430 (0%) | 0% | 0 | Ordinary Shares | |
| Titus B. Ball | Principal Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 24,427 | 47,905 (0%) | 0% | 0 | Ordinary Shares | |
| Titus B. Ball | Principal Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 15,340 | 15,340 | - | - | Share Option (Right to Buy) | |
| Xiaobin Wu | President, COO & GM China | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 253,409 | 1,268,849 (0%) | 0% | 0 | Ordinary Shares | |
| Xiaobin Wu | President, COO & GM China | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 477,386 | 477,386 | - | - | Share Option (Right to Buy) | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 34,151 | 34,151 | - | - | Share Option (Right to Buy) | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 16,341 | 46,241 (0%) | 0% | 0 | Ordinary Shares | |
| Lai Wang | Global Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 318,253 | 318,253 | - | - | Share Option (Right to Buy) | |
| Lai Wang | Global Head of R&D | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 168,935 | 1,768,962 (0%) | 0% | 0 | Ordinary Shares | |
| Julia Wang | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 136,240 | 456,326 (0%) | 0% | 0 | Ordinary Shares | |
| Julia Wang | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 256,659 | 256,659 | - | - | Share Option (Right to Buy) | |
| Alessandro Riva | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 34,151 | 34,151 | - | - | Share Option (Right to Buy) | |
| Alessandro Riva | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 16,341 | 45,955 (0%) | 0% | 0 | Ordinary Shares | |
| Margaret Dugan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 16,341 | 45,955 (0%) | 0% | 0 | Ordinary Shares | |
| Margaret Dugan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 34,151 | 34,151 | - | - | Share Option (Right to Buy) | |
| Chan Henry Lee | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 98,085 | 269,399 (0%) | 0% | 0 | Ordinary Shares | |
| Chan Henry Lee | SVP, General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2024 | 184,795 | 184,795 | - | - | Share Option (Right to Buy) | |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 149.79 per share. | 09 Apr 2024 | 2,641 | 12,144 (0%) | 0% | 149.8 | 395,604 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 150.85 per share. | 09 Apr 2024 | 60 | 12,084 (0%) | 0% | 150.9 | 9,051 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 146.09 per share. | 09 Apr 2024 | 5,008 | 7,076 (0%) | 0% | 146.1 | 731,609 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 147.74 per share. | 09 Apr 2024 | 2,811 | 0 (0%) | 0% | 147.7 | 415,306 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 149.15 per share. | 09 Apr 2024 | 12,501 | 14,785 (0%) | 0% | 149.2 | 1,864,573 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 146.82 per share. | 09 Apr 2024 | 4,265 | 2,811 (0%) | 0% | 146.8 | 626,170 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 152.28 per share. | 09 Apr 2024 | 542 | 49,458 (0%) | 0% | 152.3 | 82,538 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 153.47 per share. | 09 Apr 2024 | 2,734 | 46,724 (0%) | 0% | 153.5 | 419,592 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 154.21 per share. | 09 Apr 2024 | 7,924 | 38,800 (0%) | 0% | 154.2 | 1,221,947 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 148.40 per share. | 09 Apr 2024 | 11,514 | 27,286 (0%) | 0% | 148.4 | 1,708,634 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 184.17 per share. | 12 Mar 2024 | 100 | 0 (0%) | 0% | 184.2 | 18,417 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 179.33 per share. | 12 Mar 2024 | 993 | 807 (0%) | 0% | 179.3 | 178,072 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 180.26 per share. | 12 Mar 2024 | 307 | 500 (0%) | 0% | 180.3 | 55,339 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 181.36 per share. | 12 Mar 2024 | 200 | 300 (0%) | 0% | 181.4 | 36,273 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 182.62 per share. | 12 Mar 2024 | 200 | 100 (0%) | 0% | 182.6 | 36,525 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 162.74 per share. | 12 Mar 2024 | 6,598 | 43,402 (0%) | 0% | 162.7 | 1,073,744 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 163.78 per share. | 12 Mar 2024 | 15,466 | 27,936 (0%) | 0% | 163.8 | 2,533,011 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 164.49 per share. | 12 Mar 2024 | 12,069 | 15,867 (0%) | 0% | 164.5 | 1,985,202 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 165.49 per share. | 12 Mar 2024 | 2,602 | 13,265 (0%) | 0% | 165.5 | 430,599 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 166.44 per share. | 12 Mar 2024 | 733 | 12,532 (0%) | 0% | 166.4 | 122,003 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 169.05 per share. | 12 Mar 2024 | 200 | 12,332 (0%) | 0% | 169.1 | 33,810 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 176.35 per share. | 12 Mar 2024 | 2,737 | 9,595 (0%) | 0% | 176.3 | 482,663 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 177.11 per share. | 12 Mar 2024 | 5,994 | 3,601 (0%) | 0% | 177.1 | 1,061,601 | American Depositary Shares |
| John V. Oyler | Director, Chief Executive Officer | Sale of securities on an exchange or to another person at price $ 178.10 per share. | 12 Mar 2024 | 1,801 | 1,800 (0%) | 0% | 178.1 | 320,757 | American Depositary Shares |
| Donald W. Glazer | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 11 Mar 2024 | 82,020 | 2,702,123 (0%) | 0% | 0 | Ordinary Shares | |
| Olivier Raymond Brandicourt | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Feb 2024 | 27,794 | 27,794 | - | - | Share Option (Right to Buy) | |
| Julia Wang | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 167.08 per share. | 29 Feb 2024 | 397 | 0 (0%) | 0% | 167.1 | 66,331 | American Depositary Shares |